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This was often accompanied by enrichment of pro-inflammatory Proteobacteria and depletion of protective phyla such as Verrucomicrobia, indicating a shift toward inflammation and barrier dysfunction (Stolfi et al., 2022)

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The antioxidant effects of uric acid have been proposed particularly in conditions such as multiple sclerosis, Parkinsons disease, and acute stroke [13, 3335]

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GLP-1RAs can also exert anti-inflammatory effects on macrophages as well as regulating macrophage phenotype [65]

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